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Additionally, we focus on the limitations of mitochondrial therapy in clinical applications, and discuss potential future research directions for mitochondrial therapy

10.1016/0300-483X(89)90076-0 8

This review critically evaluates the current standard of care (SOC) and synthesizes the preclinical insights and clinical trial data, examining both successes and failures to highlight challenges in drug development

In addition, circulating GLP-1 enters circumventricular areas of the CNSsuch as the subfornical organ, the organum vasculosum of the lamina terminalis, the median eminence near the arcuate nucleus, and the area postremathanks to the partial permeability of the bloodbrain barrier.2,3,6 In addition, NTS neurons, which receive peripheral afferent input, synthesise preproglucagon and serve as a source of GLP-1 within the CNS