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If the animal studies are any indication, MOTS-c could become a powerful ally in combating diabetes, obesity, age-related decline, and chronic fatigue

PARPs (poly(ADP-ribose) polymerases) use large amounts of cellular NAD+ during DNA damage repair

In bladder cancer, it induces ferroptosis mainly by inhibiting GPX4 expression (68)

To exert a bacteriostatic effect, the metabolites bind to bacterial ribosomes and stop protein synthesis in addition to inhibiting enzymes involved in the citric acid cycle and those in charge of DNA and RNA synthesis

495 However, DHODH inhibition in SOD2-depleted cells reduced oxidative stress, lipid peroxidation, and ferroptosis, improving survival and colony formation, suggesting that DHODH activity sustains radiation-induced ferroptosis