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After testing the biochemical parameters of each organ, organ indices were calculated and histomorphological changes were monitored

Development and optimisation of alternative methods and approaches Main gaps identified: high rate of misleading/false genotoxic positives Existing in vitro methods, whilst having a high sensitivity (and thus low false negative rate), have a relatively low specificity and thus high rate of false (misleading) positive results, which typically has led to unnecessary follow-up testing in vivo for the confirmation of these results

Here are some potential causes: Genetic Predisposition: Keratosis pilaris often runs in families and is believed to have a genetic component

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If a sample screens positive for a prohibited substance or method, the lab will always perform robust and targeted confirmation procedures using the A sample