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The drug-targeting efficiency (DTE) and direct transport percentage (DTP) metrics have been established to estimate nose-to-brain drug delivery

Red lines represent frameshifts for the same genes

Cardiorespiratory exercise testing in clinical oncology research: systematic review and practice recommendations

Therefore, considering that cells do not appear to become refractory to repeated activation of the NRF2 pathway by drugs, it is possible that cancer cells utilize a non-mutated pathway to support tumor growth in early stages (Perera and Bardeesy, 2011)