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Heidari R, Ahmadi A, Mohammadi H, Ommati MM, Azarpira N, Niknahad H (2018) Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance

The residues were mixed with 20 L of 20 mM HCl, 60 L of the sodium borate buffer provided with the AccQ Tag Ultra Derivatization Kit, and 20 L of 0.3% (w/v) AccQ acetonitrile solution and heated at 50 C for 10 min to obtain their AccQ derivatives

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Thus, HIF-2-induced fatty acid synthesis using glutamine-derived citrate can be therapeutically targeted in several cancers, especially ccRCC