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This indirect yet potent strategy is particularly effective against tumors with heightened dependency on antioxidant systems, a metabolic phenotype commonly seen in cancers with oncogenic activation MYC, KRAS or loss of tumor suppressors such as p53

While BIO89-100 has been reported to be a balanced agonist of FGF21s receptors in vitro , the smaller magnitude of effect on adiponectin compared to efruxifermin suggest that BIO89-100 may not have maximally stimulated FGFR1c signaling in adipose tissue at the doses tested in humans ( Figure 3B )

The spray is commonly employed to relieve symptoms like hot flashes, night sweats, and vaginal dryness in postmenopausal women

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