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There are a few mechanisms of LINE1 hypomethylation studied: [1] LINE1 hypomethylation increases the oxidative stress in bladder cancer, thereby promoting tumor progression [139] and [2] hypomethylation of the LINE1 promoter can induce an alternate splice variant of MET oncogene in bladder tumors, leading to tumor progression [140, 141]

Antioxidants & redox signaling , 19 (13), 15391605

Solid-phase peptide synthesis dominates the industry, but newer recombinant production methods can reduce costs for certain peptides

In addition, some nanoparticles can regulate various immune cells through directly targeting immune cell subtypes to exert anti-tumor effects

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