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Nevertheless, some experts have recommended that long-term treatment with thiols should be used in patients with exacerbation phenotype without chronic bronchitis, particularly in those with early stages of COPD with less severe airway obstruction, bronchiectasis with COPD overlap phenotype, and bronchitic phenotype with or without history of exacerbation [105]

Cardiomyopathy and cardiac arrhythmias leading to sudden death are most frequently reported [64]

Sonawane A, Hastekar A, Kakad A, Shaikh MR, Sharma R

With high-dose methotrexate-based therapy, 2-year survival rates reach 4280.8%

[DOI] [PubMed] [Google Scholar] 17.Jones F, Jones P