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Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models

Lifestyle Habits: Diet, sun exposure, and skincare routine can affect the outcome

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As research advances, these applications could transform how we manage sepsis, ischemia, and other conditions tied to ferroptosis and oxidation

Moreover, sorafenib-associated heart failure was reported in treatment of advanced stage hepatocellular carcinoma [135]