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& Spencer, K

Oxidative stress is a pathological state caused by an imbalance between the excessive generation of reactive oxygen species (ROS) and the bodys antioxidant defenses (43)

We further discuss therapeutic strategies targeting metabolic pathways, including repurposed drugs (metformin, hydroxychloroquine, rapamycin), preclinical small molecules (PKM2, PFKFB3, LDHA, GLUT1 inhibitors), and combination therapies with biologics

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Certain plant compounds, like those found in curcumin and ginkgo biloba, have been investigated for their potential to modulate these receptors [49, 55, 56]