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The potentially beneficial features of IgE include its affinity for the FcR, expressed by the immune effectors responsible for ADCC and ADCP, and the low levels of normal IgE in the blood, which avoids competition with the therapeutic IgE

plasmid #136466, Watertown, MA, United States) plasmids were performed with the transfection reagent FuGENE HD (Promega, Ref: E2311, Promega GmbH, Walldorf, Germany) at a 2:1 FuGENE HD:DNA ratio according to the manufacturer protocol

Recent bioinformatic analyses based on GEO datasets (GSE51588 and GSE55457) identified LPCAT3 as one of the ferroptosis-related differentially expressed genes significantly downregulated in OA tissues

Thanks to the Vegan Society for allowing us to link to their website: Devalia V et al (2014) Guidelines for the diagnosis and treatment of cobalamin and folate disorders [Accessed 29.11.19] Linnebank et al (2011) Antiepileptic drugs interact with folate and vitamin B12 serum levels [Accessed 22.10.19] Sukumar and Saravanan (2019) Investigating Vitamin B12 deficiency [Accessed 29.11.19]

Thus, iron overload and metabolism dysfunction was thought to play a pivotal role in mTBI pathophysiology