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Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

This paper goes further and points towards a radical and emerging third bold direction in comparative research that involves reversing the gaze, shifting the perspective entirely to those traditionally viewed as peripheral, using their experiences and frameworks as the primary lens for comparison

the antibodies of the invention may inhibit tumor growth by at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, or at least about 90%, at least about 100%, at least about 110%, at least about 130%, at least about 140%, at least about 150%, at least about 160%, or at least about 170% as compared to control antibodies in a mouse xenograft model described herein

However, ambiguities remain since the studies did not consider the damaging effects of reductive stress that precedes oxidative stress in hyperglycemia on mitochondria and malfunctioning feedback mechanisms (142)

Lipid AGEs are elevated in diabetic patients compared with healthy controls, and accumulation of lipid AGEs appears to contribute to vascular diseases related to diabetes (Fishman 2018)