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doi: 10.1016/j.matbio.2018.05.008 139

Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue

On the other side, Mn 2 could catalyze the conversion of endogenous HO intoOH, facilitating tumor CDT, and subsequently inducing immunogenic cell death in tumor cells, finally augmenting immunotherapy