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Understanding the intersections between metabolism and Cancer biology

In GNMT-KO mice, with the deletion of exons 1-5 of the GNMT gene, HCC grows at the age 14-24 months of age, especially in female mice [1]

(7) cytosolic K+ loss as a metabolic switch and a regulator of autophagy

When this equilibrium collapses, misfolded, aggregated, or damaged proteins accumulate, driving organelle dysfunction, maladaptive stress signaling, and disease progression