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Polyphenols have a chemical structure with properties that make them the compounds with the greatest antioxidant action: o -diphenolic group, 2-3 double bond conjugated with the 4-oxo function and hydroxyl groups (OH) in positions 3 and 5 (Ruiz et al., 2009)

doi: 10.1016/j.jsbmb.2019.105499 175 IshikawaKTanakaAKogameAWatanabeTTagawaYMatsuiH

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Notably, excessive ROS can further exacerbate calcium homeostasis disorders by damaging the sarcoplasmic reticulum Ca-ATPase and mitochondrial calcium uniporter, forming a malignant cascade of excessive ROS-calcium imbalance-energy crisis [136]

Initially, at least 15 to 20 applications should be necessary for this