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Small molecular kinase inhibitors can block phosphorylation of the catalytic domain in the receptor by competitive or non-competitive antagonism of the ATP binding site, thereby preventing the recruitment of signal transducers and mediators, and thus impeding the transmission of downstream signals (Munshi et al., 2010

[0350] Various delivery systems are known and can be used to administer the pharmaceutical compositions described herein, e.g., encapsulation in liposomes, microparticles, microcapsules, recombinant cells capable of expressing the mutant viruses, receptor mediated endocytosis (see, e.g., Wu et al., 1987, J

79 Additionally, precursors, synthetic approaches and post-synthesis treatments can also greatly affect their BBB penetration capacity

Cycling: Time-limited protocols rather than continuous use reduce annual costs