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731 Pharmacological inhibition of USP14 effectively reduces the level of NCOA4 to protect neurons from ferritin-mediated ferroptosis

The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

Source of chronic inflammation in ageing High levels of pro-inflammatory cytokines shape the ageing-associated pro-inflammatory status, although the source of ageing-related chronic low-grade inflammation remains incompletely understood

doi: 10.1016/j.trecan.2015.10.002 2 MullerFLCollaSAquilantiEManzoVEGenoveseGLeeJet al

however, lack of selectivity for tumor cells and nonspecific organ toxicity restricts its clinical application [188, 190,191,192]