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Pre-clinical Research The development of new medicines begins with preclinical research, which lays the groundwork for clinical testing in humans

Associated hyperalgesia and allodynia soon follows, however, in a time frame too short to be explained by the classical model of synaptic plasticity by nuclear transcription and cytoplasmic translation

Neuron 80 , 624632 (2013)

The goal of pharmacotherapy is to find medication/medications that provide significant pain relief with minimal side effects

In a series of more than 80 targets investigated, L-NAME and L-arginine exhibited the opposite, but also the parallel effects