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LOXs activation can also be blocked when the cell is in a redox state, such as the activation of GPX4[102]

It is worth dwelling on why the wound-chamber design is methodologically valuable, because it is what elevates the strongest reports above a simple observation

As bacterial-derived LPS has a key role in the increase in gut permeability, changes in the gut microbiota must be a contributory factor to the pathogenesis of obesity and diabetes 109

Furthermore, a role for the FODMAP (eg, fructans) component of wheat as the sole trigger for symptoms is somewhat doubtful, because many patients with NCWS report resolution of symptoms after the withdrawal of wheat and related cereals, while continuing to ingest vegetables and fruits with high FODMAP content in their diets.59 On the whole, it is conceivable that more than one culprit may be involved in symptoms of NCWS (as they are currently defined), including gluten, other wheat proteins, and FODMAPs.6062 "Nonceliac Gluten Sensitivity: What Is the Culprit?"

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