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Metformin treatment (2.5 mM and 10 mM) also significantly sensitised radioresistant SW837 cells to 1.8 Gy X-ray radiation, when compared to vehicle control ( Figure 1G ) (relative mean SF SEM

5L) indicated that NR conversion to NAD depends on ATP supply via 23 enzymatic steps ( NadR / NAPMT -dependent) or via nicotinamide (NAM) conversion, which requires multi-step processes (NAM NaMN NaAD NAD)

Altered lipid compositions of the membrane might be the key factor linking ferroptosis and necroptosis

doi: 10.33549/physiolres.931585 35

In summary, the interaction between ferroptosis and mitochondrial damage in DCM forms a vicious cycle: from iron overload to oxidative damage and ultimately to cell death