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Unlike when we assign a service to a clinical APC and consider resource and clinical similarities to other services in a clinical APC, we assign services to New Technology APCs based on cost

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The identity of all the tested compounds was confirmed by 1H NMR and HPLC-MS, and the purity was ensured to be 95% (see Supporting Information)

5 Using elevated metabolite levels (ie, serum methylmalonic acid [MMA] or homocysteine [Hcy]) to define deficiency, the screening serum B 12 cutoff used in many diagnostic algorithms has been raised to 250 pg/mL to 300 pg/mL to provide greater sensitivity

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