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Compared to livers from control mice, those from HFD-fed mice showed a significantly increased percentage of methylation at the CpG islands of CYP2R1 (Fig

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2321-C HEPATOCYTE HEDGEHOG ACTIVITY CONTROLS NAFLD SEVERITY BY REGULATING SENESCENCE-ASSOCIATED SECRETOME Ji Hye Jun 1 , Kuo Du 2 , Seh-Hoon Oh 2 , Raquel Maeso Daz 2 , Rajesh Kumar Dutta 3 , Anna Mae Diehl 2 and Duke University, (1)Duke Universty, NC, (2)Duke University, (3)Duke University, Durham, NC Background: NAFLD and other inflammatory liver diseases induce hepatocyte DNA damage and senescence

Knapen MF, Mulder TP, Van Rooij IA, Peters WH, Steegers EA