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This must be due to a lower clearance (CL) of drug B, since it was shown above that the volume of distribution is similar for both drugs

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These effects could also be partly regulated by increased levels of endocannabinoids or through TRP channels, since CBD has a relatively high affinity for TRP vanilloid receptor 1 (TRPV1), which has been shown to modulate cytokine production in microglia (Stampanoni Bassi et al., 2019)

Pavlkov D, Pavlk M, Prochzkov D et al (2014) Nitrogen metabolism and gas exchange parameters associated with zinc stress in tobacco expressing an ipt gene for cytokinin synthesis

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