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Activated LINE elements generate abundant RNADNA hybrids, which are recognized as foreign nucleic acid signals by the cGAS-STING pathway, inducing immune responses and amplifying inflammatory signals closely linked to neuroinflammation in AD

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Using LRA results we predicted their ability to express GSTA1

Moreover, epigenetic modulation appears to be an important contributor to endothelin-induced expression of pro-inflammatory genes in VSMCs (Yang et al., 2014)