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IF also regulate the peroxisome proliferator-activated receptor coactivator 1 (PGC-1), a transcription factor of mitochondria function, in neurons (Wilhelmi de Toledo et al., 2020

These stressors create free radicals

Cancer cells, unable to utilize ketone bodies produced by KD for energy due to their aberrant mitochondrial function and diminished enzyme activity, can essentially be starved of glucose

The redox energy supply of nicotinamide adenine dinucleotide (NAD + ) is vital to glycolysis and the tricarboxylic acid cycle (TCA), forming free NADH (reduced form) in the mitochondria