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Piperine was observed to directly reduce the phosphorylation of NF-B and the expression of NF-B target genes associated with RA-FLS proliferation, apoptosis inhibition, and inflammation

This indicates that synthetic derivatives of natural products are usually more likely to be approved as drugs than themselves, and structural modifications will become a key bridge for successfully converting natural products into new pharmaceuticals [364]

Cytokine Growth Factor Rev 53:6670

This review consolidates current knowledge and provides a mechanistic framework to guide therapeutic strategies that aim to intercept cancer resistance in the earliest and most reversible stages of its development

Moreover, it brings hope for early detection and intervention, with the potential to prevent these disorders from taking root