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doi: 10.1016/j.scienta.2012.06.006 37 SmoleS.RozekR.Ledwozyw-SmolenI.StrzetelskiP

Role of anti-M1 agent in modulating M2 macrophages and preventing fibrosis The anti-M1 agent acts as an immune modulator to shift the balance between pro-inflammatory and pro-repair responses, ultimately preventing excessive fibrosis

Less toxic agents such as Brincidofovir are not widely available ( via inhibition of the UL97 protein kinase

Amino acids, the building blocks of proteins, are central to metabolic pathways and also participate in immune regulation and the inflammatory response