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28 days) improves cognitive function in the cognitive impairment model of aged rats, enhances synaptic plasticity in the hippocampus, and increases the expression of brain-derived neurotrophic factor (BDNF) [3]

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AR phase separation Despite these important new insights, because of the notoriously highly disordered structure of the AR NTD, the latter study used NTD-truncated AR to derive structural information, which may have limited the scope and the therapeutic potential of this information

Finally, Villardita et al 36 evaluated ALC versus placebo, but did not report depressive-symptom efficacy results in a way that could be summarized quantitatively