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Due to the already sensitive nature of dopaminergic neurons to redox imbalance and ROS generation, the additional reduction of an antioxidant like GSH causes neuron loss (Smeyne and Smeyne, 2013)

The LDL oxidative reactions involve low levels of lipid hydroperoxides or oxidants, which lead to oxidative degradation of the heme and the release of heme iron (Sadrzadeh and Eaton, 1988)

Despite these promising effects in DN, the underlying molecular mechanisms and specific pharmacological targets remain poorly elucidated

9 The Nutrient Reference Value (NRV) used on supplement labels is 55 g