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This disconnect between in vivo and human studies might be due to the different sample characteristics, inter-individual variabilities related to past history of drug use, consumption rate, psychological problems, and differences in the experimental methodology (Matochik et al., 2005

On 3D EM, mitochondrial cristae spacing was less with ET and consistently, on RNAseq, cristae formation geneset showed significant alterations ( Fig1C )

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Vegetarians and vegans, since B12 is primarily found in animal-based foods, may experience a deficiency that can become significant over time