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The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components

Clinically, HD is characterized by progressive motor dysfunction, cognitive decline, and psychiatric disturbances, all of which together contribute to substantial long-term disability and reduced quality of life [111]

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doi: 10.3390/pharmaceutics14102014 [DOI] [PMC free article] [PubMed] [Google Scholar] 73.Bhargava A, Osusky M, Hancock RE, Forward BS, Kay WW, Misra S

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