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The Take-Away Its important to note that while many people report positive effects from MIC/B-12 injections, the evidence supporting these benefits is limited

Neelakantan et al., Biochemical Pharmacology, 2018, gave diet-induced obese mice the compound and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with food intake unchanged (PMID 29155147) [3]

Failure to do so may lead to a variety of health issues, including anemia, fatigue, muscle weakness, intestinal problems, nerve damage, and mood disturbances

In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

Sculptra is very rarely used in the chin for augmentation, but both Sculptra and Radiesse can theoretically be at least partially dissolved, though its less of a guarantee than an HA filler and generally a slower process