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This review discusses the potential of CD19 CAR-T cells in ARDs, highlighting clinical achievements and addressing key considerations such as optimal target cell populations, CAR construct design, acceptable toxicities, and the potential for lasting immune reset, crucial for the safe and effective adoption of CAR-T cell therapy in autoimmune treatments

Mol Biol Evol 28(10):27312739 Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger

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This action of MDM2 explains the earlier results that inhibition of wild-type p53 unexpectedly leads to downregulation of the IGF-1R (Girnita et al, 2000)