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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

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Investigators observe how this pentadecapeptide interacts with focal adhesion kinase (FAK) and paxillin cascades to physically guide structural cells to wound sites, balancing local nitric oxide signaling to stabilize endothelial cell survival curves