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These products, particularly those that are injected, can carry significant safety risks, including contamination, infection or local tissue damage

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Outcomes depend on study design, dosage, and formulation

To define IGF-I/IGF-IR actions in chondrocytes, cartilage-specific IGF-IR KO mouse models ( cart IGF-IR / mice) were made by crossing floxed IGF-IR mice that carried loxP sequences flanking the exon 3 of the gene (30) with mice expressing Cre recombinase transgene, under the control of a type II collagen promoter (31)

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