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In their review article, Cardiovascular Toxicity of Nicotine: Implications for Electronic Cigarette Use, published in 2016 in the journal Trends in Cardiovascular Medicine, Neal Benowitz and Andrea Burback, write that The cardiovascular safety of nicotine is an important question in the current debate on the benefits vs risks of electronic cigarettes and related public health policy. Their findings affirm the argument that short-term use of e-cigarettes (as well as smokeless tobacco and nicotine medications) pose a low cardiovascular risk in healthy users

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Moreover, we showed that smoking initiation in adolescence and in early adulthood both significantly elevate the risks of cardiovascular and mortality compared to starting smoking at age 30 or above