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A deficiency can also cause issues such as diarrhea, nausea, vomiting, lack of appetite, weight loss, pale skin, numbness and tingling in your hands and feet, confusion, irritability, depression, and behavior changes

Toxicity from high doses of B12 is fairly unlikely as it is a water-soluble vitamin, so any excess will be flushed out

MAPK: mitogen-activated protein kinase

Vitamin B12 functions in the body through two bioactive coenzymes: Methylcobalamin Functions in the cell plasma as a coenzyme in the methylation cycle Adenosylcobalamin Functions in the mitochondria as a coenzyme in the citric acid cycle Through these two functional mechanisms, multiple effects take place in diverse biological systems as explored in our article: Vitamin B12 Benefits The focus of this article is on methylcobalamin and its working within the methylation cycle

Used for treating folate deficiency anemia and preventing neural tube defects during pregnancy