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HILIFE PLUS

Rossner et al., 2016

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Interaction with the designed ankyrin repeat protein does not affect p53 DNA binding or the crucial MDM2 negative feedback loop but reactivates a p53-dependent transcriptional program in HeLa (HPV18-positive) and SiHa (HPV16-positive) cells, suggesting a potential therapeutic use

Numerous hydrophobic interactions of the methoxy group and a hydrogen bonding network between the N 1 amine group, histidine H63, and heme point are crucial for KDS12025 (Fig