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Anyone on long-term metformin, PPIs, or a GLP-1 protocol with significantly reduced intake for months should have B12 checked as part of routine monitoring

The use of MAO inhibitors within one week of trazodone therapy is also not recommended

Vitamin B12 deficiency can arise from various factors, including dietary deficiencies, malabsorption syndromes, or certain medical conditions

These people would otherwise rely on the availability of daily B12 shots to counter their inability to absorb B12 through the gut

It is still harmless if you take a vitamin B12 supplement at a dose higher than the recommended daily allowance, which is 2.4 micrograms for adults