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doi: 10.1093/jn/137.4.890

1992;267:3758-3763 Vukovich M.D., Costill D.L., Fink W.J

International Journal of Innovative Science and Research Technology pp

While the effects on the development of levodopa-related motor complications require long-term trials in de-novo subjects, the EPSILON study of early opicapone adjunct in levodopa-treated subjects without motor complications has recently provided evidence for beneficial effects on motor control without increasing motor complication risk over 76 weeks