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Though the mechanism behind this is unclear, it is hypothesized that magnesium helps with relaxation by acting on certain brain chemicals

[69] reported that isoflurane-induced drug preconditioning used to treat acute myocardial stress could not generate NAD+ benefits in elderly rats and was directly related to the mitochondrial damage caused by a decrease in GSK-3 phosphorylation

Trends Plant Sci 6:177183 Whiteman SA, Serazetdinova L, Jones AM, Sanders D, Rathjen J, Peck SC, Maathuis FJ (2008) Identification of novel proteins and phosphorylation sites in a tonoplast enriched membrane fraction of Arabidopsis thaliana

Combined strategy with classic antioxidants Classic antioxidants (e.g., vitamin C and E, NAC) show contextual benefits but heterogeneous outcomes when used indiscriminately