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Clinicians therefore need to know not only the half-life of the drug that they are prescribing but also what the half-life might be given the presence of one or more of these factors in the patient to whom the drug is being prescribed

However, vitamin B 12 deficiency does not generally develop until after at least two-to-three years of continuous therapy (137-139)

Improving insulin sensitivity can also help manage high blood pressure, reducing the risk of heart disease

The deficiency is isolated to B12 without the need for multi-nutrient replenishment

Five years after treatment or remission is used as a conservative review window rather than a proven biological cutoff