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Among the subjects, 64 (40%) were women, 123 (77%) identified as white, and the median age was 55 (IQR 45-62) years

Younger reproductive age people might experience wound healing faster while perimenopausal folks frequently observe mood or sleep changes instead of reproductive results

4.2 Combined strategies of immune, antivascular, and radiotherapy based on metabolic pathways Metabolic remodeling, vascular normalization, and T-cell infiltration can form a synergistic cascade: inhibiting HIFVEGF signaling and dysregulated lipid metabolism may reduce myeloid-mediated immunosuppression, improve perfusion and oxygenation, and enhance CD8+ T-cell effector function, thereby providing a metabolic rationale for synergy between TKIs/VEGF inhibitors and ICIs

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