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It has been reported that GPX3 and GPX4 labeling are absent in the spiral ganglia, while GPX1 is the major isoform of GPXs family that highly expressed in cochlear SGNs in adult rat (Kil et al., 2007)

Acknowledgements The authors gratefully acknowledge the support and insightful feedback provided by co-workers and affiliated institutions during the preparation of this Review

Clinical diagnosis The study design and clinical diagnosis have been previously described 22

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