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AGEs comprise a heterogeneous group of bioactive adducts and cross-linked products formed through non-enzymatic reactions between reducing sugars and free amino groups in proteins (commonly lysine or arginine), as well as lipids and nucleic acids, via processes collectively related to the Maillard reaction 30,31,32

While the exact etiology of depression is still under investigation, inflammation has emerged as a significant factor in its development (Barton, 2008)

10.1017/S0029665117002026 Proc

Thelwall, M., Buckley, K., Paltoglou, G., Cai, D., & Kappas, A

Focusing on such molecules, along with promising therapeutic candidates like Epigallocatechin gallate and tofacitinib, offers encouraging strategies for targeted interventions in RM (Xie et al., 2024)