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One of the reasons for ectopic fat deposition could be a slow increase in body weight (210 kg) during the adult life due to increase in adiposity ( Reference Ruderman, Chisholm and Pi-Sunyer 47 )

In this context, acetylcarnitine may have a cardioprotective effect against cisplatin-induced cardiotoxicity at the oxidative stress level via modulation of SOD levels [143]

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Importantly, 1a R -IN-8 with its reversible cyclohexenone-based warhead inhibited none of the 20 off-target kinases (Supplementary Table 3)

We hope to provide inspiration and ideas for future studies in the mechanism and targets of HO-1 through this review