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PMCID: PMC5765813

As well as BH4 supplementation, a promising strategy may be to normalize BH4 levels in the endothelium by either reducing oxidative stress with pharmacological agents such as ascorbic acid, or as suggested by more recent investigations, to protect against the accumulation of oxidized forms of tetrahydrobiopterin, such as BH2 and biopterin by activation of the recycling pathways of biopterin synthesis

Hesperidin Protects skin cells from oxidative damage

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the main enzyme involved is therefore uridine diphosphate glucuronosyl transferase (UDPGT)