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Indian journal of pharmaceutical sciences 73 , 152158 (2011)

Most people notice the first changes in physique and body circumferences after about 2-4 weeks of systematic use, while maintaining healthy eating habits

Results develop gradually over 6-12 weeks for puffiness and pigmentation, 3-6 months for vascular improvement through skin thickening, requiring patience and consistency following realistic timelines

Hence, total plasma or serum B12 concentration includes B12 (cobalamin) bound to transcobalamin (holoTC) and B12 bound to haptocorrin