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Roche, Lorraine Brennan, Nigel Irwin PLOS ONE.2016

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64 CONCLUSION Emphysema is one component of COPD and is often asymptomatic for many years before symptoms develop

Moreover, several clinical studies have identified elevated levels of numerous inflammatory markers, including CRP, TNF-, IL-1RA, sTNFR1, and sTNFR2, along with elevated serum NF-B levels, in patients with DPN compared to patients with T2DM without neuropathy, suggesting that patients with DPN exhibit a more pronounced inflammatory response (9698)

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