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Cerebrovascular hemodynamics in Alzheimers disease and vascular dementia: a meta-analysis of transcranial doppler studies

Brignull et al

c-Myc not only promotes the expression of LDHA to convert pyruvate to lactate, thereby promoting the extramitochondrial metabolism of pyruvate, but also increased the expression of mitochondrial transcription factor A and increases mitochondrial mass [142, 143]

& Tollefson, M

Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)